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Weight loss drugs - what you should know

If you watch any television at all, you've probably seen the commercials for the diabetes drug Ozempic, with a catchy jingle set to the tune of the Scottish rock band Pilot's 1974 hit "Magic." And even though onscreen text informs viewers that Ozempic is not a weight loss drug, the commercial still touts weight reduction as a benefit.

The marketing clearly works -- according to CNN, pharmacies filled more than twice as many Ozempic prescriptions during the last week of February 2023 compared with the same week in 2022.


While Ozempic can only be prescribed off-label as a weight loss aid, a higher-dose version called Wegovy, developed specifically for weight loss, received approval from the U.S. Food and Drug Administration (FDA) last year. Tirzepatide, marketed by drugmaker Eli Lilly under the brand name Mounjaro, may become the most potent anti-obesity medication on the market if the FDA grants Lilly's application for fast-track approval as a weight loss drug, according to the Associated Press.

All three medications, part of a class of drugs called GLP-1 receptor agonists, mimic hormones that activate after eating to help regulate blood sugar and slow digestion. The slowed digestion leaves patients feeling full for longer after each meal, which leads to lower overall caloric intake. In addition to GLP-1, Mounjaro targets a second hormone that Eli Lilly says can affect even more significant weight loss.

According to the Associated Press, the drugs seem to be effective for the long-term treatment of obesity, and, by extension, can lower risks for conditions associated with obesity. In clinical trials for Mounjaro, participants lost as much as 22 percent of their body weight, compared to just 3 percent in the placebo group.

It's not all smooth sailing, though -- common side effects including nausea, vomiting, constipation, diarrhea, and stomach pain. Medicare and most private insurance plans also don't cover weight loss drugs, so patients must pay the full cost, which can top $1,300 each month. And if they stop taking the drugs, the weight usually comes right back.


This story was posted on 2023-06-29 07:04:42
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